کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560 400 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model
چکیده انگلیسی

Extensive urethral defects have a serious impact on quality of life, and treatment is challenging. A shortage of material for reconstruction is a key limitation. Improving the properties of biomaterials and making them suitable for urethral reconstruction will be helpful. Previously, we constructed a fusion protein, collagen-binding VEGF (CBD-VEGF), which can bind to collagen scaffold, stimulate cell proliferation, and promote angiogenesis and tissue regeneration. We proposed that CBD-VEGF could improve the performance of collagen in reconstruction of extensive urethral defects. Our results showed that collagen scaffolds modified with CBD-VEGF could promote urethral tissue regeneration and improve the function of the neo-urethra in a beagle extensive urethral defect model. Thus, modifying biomaterials with bioactive factors provides an alternative strategy for the production of suitable biomaterials for urethral reconstruction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 69, November 2015, Pages 45–55
نویسندگان
, , , , , , , , , , , , ,