کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560265 1561743 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Placental and lactational transfer of decabromodiphenyl ether and 2,2′,4,4′-tetrabromodiphenyl ether in dam-offspring pairs of Sprague-Dawley rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Placental and lactational transfer of decabromodiphenyl ether and 2,2′,4,4′-tetrabromodiphenyl ether in dam-offspring pairs of Sprague-Dawley rats
چکیده انگلیسی


- BDE 47, -209, and their metabolites in dam were transported to their offspring.
- Debromination might occur in fetus body during gestation.
- The magnitude of lactational transfer of BDE 47 and -209 was greater than that of placental transfer.
- BDE 47 was relatively more transferred to suckling pups than BDE 209 through breastfeeding.

Although several studies have conducted maternal transfer of individual PBDE congener in experimental animals, there is a paucity of research on differences in maternal transfer of PBDE congeners. The purpose of the study was to investigate and compare placental and lactational transfer of BDE 47, -209 and its metabolites in rat dam-offspring pairs following repeated administration of BDE 47 and -209. 13C-BDE 47, BDE 209 and its debrominated congeners were detected both in dam serum and offspring body, which indicates that PBDEs can be maternally transferred. In addition, BDE 196 and -197 appeared in offspring body earlier than in maternal serum, which suggests that debromination can be occur in offspring body. BDE 209 increased in both dam and offspring while levels of 13C-BDE 47 was not increased in dam serum. 13C-BDE 47 seems to be stored in breast milk rather than in maternal serum, which can be assumed through the drastic increase of the congener in suckling pups. The magnitude of lactational transfer of the administered congeners was greater than that of placental transfer. And 13C-BDE 47 was relatively more transferred to suckling pups than BDE 209 through breastfeeding.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 102, April 2017, Pages 198-203
نویسندگان
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