کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560328 1561746 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin
ترجمه فارسی عنوان
قرار گرفتن در معرض دیاتیزیل فتالیت خوراکی دردناک درماتیت آلرژیک با استرس اکسیداتیو و افزایش لنفوپیتین استروما تامیک
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Oral DIDP exposure could aggravate allergic dermatitis.
- DIDP exacerbated allergic dermatitis through oxidative stress.
- DIDP enhanced the expression of TSLP and the activation of NF-κB and STATs.
- Melatonin alleviated allergic dermatitis by up-regulating Nrf2, HO-1 and NQO1.

Diisodecyl phthalate (DIDP) is extensively used as an environmentally friendly plasticizer. However, little is known about the adverse effects and the underlying mechanisms of DIDP exposure on immunological diseases. We aimed to determine the role and mechanisms of DIDP exposure in allergic contact dermatitis-like skin lesions. We show that oral DIDP exposure can aggravate allergic dermatitis in mice. Moreover, an increase of ROS, total serum IgE and IL-4 levels were concomitant with this deterioration. We detected the expression of Thymic stromal lymphopoietin (TSLP) and the activation of STATs and NF-κB signal pathways. The data indicated that DIDP in combination with FITC triggers TSLP production. Our results also suggested that DIDP exacerbated the activation of NF-κB signal pathways, with an enhancement in TSLP expression, which potentiated the activation of STATs and the degranulation of mast cells in the skin, and finally exacerbated allergic dermatitis. The study also suggested that melatonin enhanced the expression of Nrf2, up-regulated the antioxidant genes HO-1 and NQO1, reduced the levels of oxidative stress and TSLP, and alleviated allergic dermatitis. The results demonstrated that DIDP exacerbated allergic dermatitis through oxidative stress and enhanced TSLP production.

189

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 99, January 2017, Pages 60-69
نویسندگان
, , , , , , , , , , , , ,