کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560340 1561746 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Three-generation reproduction toxicity study of genetically modified rice with insect resistant genes
ترجمه فارسی عنوان
مطالعه سمیت نسلی سه نسل برنج ژنتیکی اصلاح شده با ژن های مقاوم به حشرات
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- A three generation toxicity experiment was carried out to study the reproductive toxicology of genetically modified rice.
- The way of feed preparation was based on maximum protein addition as the principle.
- The diets contained more than 70% of the tested rice without causing nutritional imbalance.

In the present work, we evaluated the three generation reproductive toxicity of the genetically modified rice with insectresistant cry1Ac and sck genes. 120 Sprague-Dawley (SD) rats were divided into three groups which were fed with genetically modified rice diet (GM group), parental control rice diet (PR group) and AIN-93 control diet (both used as negative control) respectively. Bodyweight, food consumption, reproductive data, hematological parameters, serum chemistry, relative organ weights and histopathology for each generation were examined respectively. All the hematology and serum chemistry parameters, organ/body weight indicators were within the normal range or no change to the adverse direction was observed, although several differences in hematology and serum chemistry parameters (WBC, BUN, LDH of male rat, PLT, PCT, MPV of female rats), reproductive data (rate of morphologically abnormal sperm) were observed between GM rice group and two control groups. No macroscopic or histological adverse effects were found or considered as treatment-related, either. Overall, the three generation study of genetically modified rice with cry1Ac and sck genes at a high level showed no unintended adverse effects on rats's reproductive system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 99, January 2017, Pages 190-198
نویسندگان
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