کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560425 1403320 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0
چکیده انگلیسی


- l-Linalool safety assessment based on RIFM's criteria.
- Safety assessment based on 7 Human health endpoints plus environmental.
- Repeated dose toxicity was determined to have the most conservative NO[A]EL.
- An acceptable MOE was obtained.

The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 97, Supplement, November 2016, Pages S11-S24
نویسندگان
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