RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7

- Benzyl butyrate safety assessment based on RIFM's criteria.
- Safety assessment based on 7 Human health endpoints plus environmental.
- All endpoints were cleared using data and/or read across.

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog benzyl acetate (CAS # 140-11-4) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the repeated dose, developmental and reproductive, and local respiratory toxicity endpoints. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.