کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5572779 | 1564815 | 2017 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association between eicosapentaenoic acid (EPA) medication intake and new onset of depression among Japanese patients with hyperlipidemia: A 3-year follow-up study
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Association between eicosapentaenoic acid (EPA) medication intake and new onset of depression among Japanese patients with hyperlipidemia: A 3-year follow-up study Association between eicosapentaenoic acid (EPA) medication intake and new onset of depression among Japanese patients with hyperlipidemia: A 3-year follow-up study](/preview/png/5572779.png)
چکیده انگلیسی
A number of preclinical and clinical studies have suggested that omega-3 fatty acids have a prophylactic effect against depression. The aim of this study was to explore the effect of eicosapentaenoic acid (EPA) on development of depression among Japanese patients with hyperlipidemia. This was a 3-year follow up study based on medical claims data obtained from Japan Medical Data Center. A total of 76,561 patients were eligible for the final analyses. The exposure group included EPA drug users categorized into 2 groups based on adherence to EPA using the Medication Possession Ratio (MPR) with a cutoff of 80%. The control group (non-EPA group) consisted of subjects taking lipid-lowering medications other than EPA. A Cox proportional hazard model was used to evaluate the association between EPA drug use and the development of depression. Over 3 year-follow up, 1319 (1.7%) patients developed depression. In the multivariate Cox proportional hazard model, no association was found between depression and EPA drug use in the MPR â¥80% group (HR:0.89, 95%CI: 0.67 to 1.20) or MPR < 80% group (HR:1.00, 95%CI: 0.73 to 1.37) compared with the non-EPA group. No convincing evidence was found to support the association between EPA and risk of depression before and after adjusting for age, gender, and comorbidity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Nutrition & Intermediary Metabolism - Volume 9, September 2017, Pages 12-16
Journal: Journal of Nutrition & Intermediary Metabolism - Volume 9, September 2017, Pages 12-16
نویسندگان
Lin Song, Satomi Yoshida, Sachiko Tanaka-Mizuno, Yusuke Ogawa, Toshiaki A. Furukawa, Koji Kawakami,