کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
557824 | 874794 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A semantic web approach to biological pathway data reasoning and integration A semantic web approach to biological pathway data reasoning and integration](/preview/png/557824.png)
This paper describes the use of semantic web technology and Description Logic (DL) for facilitating the integration of molecular pathway data, which is illustrated by an Web Ontology Language (OWL)-based transformation of a more complex pathway structure (Reactome) into a simpler one (HPRD). The process starts by adding OWL axioms to BioPAX, a pathway interchange standard. The axioms are designed for mapping BioPAX-formatted Reactome interactions to “molecular binding event” interactions, which can be easily aligned with the HPRD data. Using an automated OWL reasoner, we find overlapping and non-overlapping molecular interactions between the two pathway datasets. The paper demonstrates the potential of semantic web and its enabling technologies in biological pathway data reasoning and integration.
Journal: Web Semantics: Science, Services and Agents on the World Wide Web - Volume 4, Issue 3, September 2006, Pages 207–215