کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5585472 | 1404361 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inflammation dans le tissu adipeux péri-artériel et athérome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
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چکیده انگلیسی
In atherosclerosis studies, there are few data, especially in men, on the biology of perivascular adipose tissue (PVAT) compared to that of other adipose tissue (AT), on amendments in obesity, and its possible role in the development of atherosclerosis. We conducted an ex vivo human study on pericarotid adipose tissue-collected in the immediate vicinity (PVATp) and away from the plate (tapas)-and subcutaneous (SC) neck gathered during surgery from patients suffering from atheromatous carotid disease. In addition, we conducted a study in obese Zucker rats (models of obesity and insulin resistance) and Wistar rats subjected to moderate stress. In these models, we collected renal adipose tissue (RAT), epididymal adipose tissue (EAT), and TAPA samples. On all samples, we measured mRNA levels encoding for proinflammatory cytokines (TNFα, IL-6, IL-1β, MCP-1). Our results showed an increase in mRNA MCP-1, TNF and IL-6 in the adipose tissue around atherosclerotic plaques, an increase that was greater in diabetics than in non-diabetic subjects; we noted for the mRNA of MCP-1 in the TAPAp, 3.49 Ã 10â2 ± 1.17 Ã 10â2 ng/ug 18S in diabetic patients compared to 7.26 Ã 10â3 ± 1.00 Ã 10â3 ng/ug 18S (**P < 0.01) in non-diabetic patients. In the obese Zucker rat, we found a significant increase in IL-6 in TAPA in obese animals compared to the corresponding controls (4.24 Ã 10â5 ± 1.75 Ã 10â6 ng/μg 18S vs 1.29 Ã 10â5 ± 1.55 Ã 10â6 ng/ug 18S). In stressed rats, we recorded a TNFα mRNA increase in the PVAT and EAT in the stressed rats compared to fatty tissue of control animals, we note respectively, 7.52 Ã 10â3 ± 2.8 Ã 10â3 ng/μg 18S vs 2.62 Ã 10â3 ± 0.57 Ã 10â3 ng/18S and 4.78 Ã 10â3 ± 1.52 Ã 10â3 ng/μg 18S vs 2.02 Ã 10â3 ± 0.3 Ã 10â3 ng/ug 18S. In summary, our work shows an inflammatory state of the TAPA surrounding the atheromatous plaques in diabetic patients. An obesity or stress state promotes an inflammatory profile of PVAT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comptes Rendus Biologies - Volume 340, Issue 3, March 2017, Pages 156-163
Journal: Comptes Rendus Biologies - Volume 340, Issue 3, March 2017, Pages 156-163
نویسندگان
Nadjiba Hamlat-Khennaf, Samia Neggazi, Hanene Ayari, Patrick Feugier, Giampiero Bricca, Souhila Aouichat-Bouguerra, Michel Beylot,