کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5585796 | 1568372 | 2017 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety-like behavior in offspring
ترجمه فارسی عنوان
درمان دیپیرن مادر در طول شیردهی در موش باعث کاهش رفتار مادران و رفتار اضطراب مانند فرزندان می شود
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کلمات کلیدی
موش، دیپیرن، متامیزول، رفتار مادرانه، فرزند اضطراب،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
چکیده انگلیسی
Dipyrone (metamizole), a powerful drug, is widely used as an analgesic and antipyretic; however, the safety of its use during lactation and the potential impact on the offspring are not well established. This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam's maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500Â mg/kg/day, were offered to lactating mothers up to PND9. Thereafter, all mice were provided regular drinking water. On PND2, all litters were culled to 8 pups (4 males and 4 females). Maternal behavior was evaluated at PND3, 6, 9, and 12, and at PND7 we evaluated locomotor activity in the open field. Reflex parameters and physical development of offspring were evaluated during lactation. At PND7, analysis of ultrasonic vocalization (USV) was performed. When the animals reached adolescence, we evaluated their performance in the open field, elevated plus maze (EPM), and marble burying. Our data demonstrated that maternal dipyrone treatment during lactation not only altered maternal behavior and the onset of physical and neurodevelopmental landmarks but also had an impact on anxiety-like behavior in offspring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 58, May 2017, Pages 74-81
Journal: International Journal of Developmental Neuroscience - Volume 58, May 2017, Pages 74-81
نویسندگان
Vanessa Barbosa Veronesi, Tatiane Helena Batista, Ana Cláudia Alves Freire Ribeiro, Alexandre Giusti-Paiva, Fabiana Cardoso Vilela,