Increased IL-35 producing Tregs and CD19+IL-35+ cells are associated with disease progression in leprosy patients

This study point out a shift in our understanding of the immunological features that mediate and regulate the immune suppression and the disease progression in leprosy patients with a new paradigm (IL-35 producing Tregs and Bregs) that is beyond TGF-β and IL-10 producing Treg cells.