کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5586909 1568714 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interferon regulatory factor signaling in autoimmune disease
ترجمه فارسی عنوان
سیگنال تنظیم کننده اینترفرون در بیماری های خودایمنی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Interferon regulatory factors (IRFs) play critical roles in pathogen-induced innate immune responses and the subsequent induction of adaptive immune response. Dysregulation of IRF signaling is therefore thought to contribute to autoimmune disease pathogenesis. Indeed, numerous murine in vivo studies have documented protection from or enhanced susceptibility to particular autoimmune diseases in Irf-deficient mice. What has been lacking, however, is replication of these in vivo observations in primary immune cells from patients with autoimmune disease. These types of studies are essential as the majority of in vivo data support a protective role for IRFs in Irf-deficient mice, yet IRFs are often found to be overexpressed in patient immune cells. A significant body of work is beginning to emerge from both of these areas of study - mouse and human.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 98, October 2017, Pages 15-26
نویسندگان
, , , ,