کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5587581 | 1568854 | 2017 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of ovarian follicular dynamics and folliculogenesis associated endocrine profiles following gonadotropin stimulation in the bonnet monkey
ترجمه فارسی عنوان
ارزیابی پوکی استخوان فولیکولار تخمدان و پروفایل غدد درون ریز وابسته به فولیکولوژنز پس از تحریک گنادوتروپین در میمون بند ناف
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کلمات کلیدی
اولیای غیر انسانی، تخمک گذاری، فولیکول پیش تخمگذار فولیکول لووتیونی باز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
We evaluated ovarian follicular dynamics in bonnet monkeys by employing trans-abdominal ultrasonography. Following the administration of human follicle stimulating hormone (hFSH) and/or human menopausal gonadotropin (hMG), multiple follicular development was assessed and their numbers, size and growth profiles were monitored. The ultrasonograms showed that the follicular antrum appeared distinctly anechoic with well-defined hyperechoic borders. Depending on the type, quantity (12.5-25Â IU), and duration (6-9Â days) of hormones administered, the number of developing follicles was 2-12 per ovary with their lowest diameter being 2Â mm. With continued hormone administration, their numbers and diameters increased; which were more pronounced in animals administered with hFSH than with hMG, with follicles of 6-8Â mm. Interestingly, human chorionic gonadotropin (hCG) injection (2000-3000Â IU), when follicles acquiring >6-8Â mm sizes, induced the maximum expansion of antral follicles with sizes reaching up to 14Â mm. On days 3-5 post-hCG, the ultrasonograms showed loosely demarcated multiple hypoechoic structures and well-demarcated hyperechoic structures with anechoic/hypoechoic cores corresponding to unruptured luteinized follicles and corpora lutea, respectively. On day 4 post-hCG, there was a substantial reduction in the number of antral follicles. In stimulated animals, follicular growth, ovulation, and formation of luteal structures were accompanied by corresponding physiological changes in the serum estradiol and progesterone profiles. These findings, for the first time, showed that ultrasonographic imaging approach is useful for precise monitoring of temporal changes in follicular developmental dynamics and to time the hCG induced ovulation in the bonnet monkey.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 253, 1 November 2017, Pages 25-32
Journal: General and Comparative Endocrinology - Volume 253, 1 November 2017, Pages 25-32
نویسندگان
Bhupathi Sukesh, Muraly Puttabyatappa, Augustine T. Peter, Rudraiah Medhamurthy, Polani B. Seshagiri,