کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5587668 | 1568857 | 2017 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ghrelin enhances food intake and carbohydrate oxidation in a nitric oxide dependent manner
ترجمه فارسی عنوان
گرلین باعث افزایش جذب غذا و اکسیداسیون کربوهیدرات به روش وابسته به اکسید نیتریک می شود
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کلمات کلیدی
N-nitro-l-arginine methyl esterRERGHSR1agrowth hormone secretagogue receptor 1AArcNl-NAME - L-NAMEAppetite - اشتهاGoat - بزPVN - مالیات بر ارزش افزودهMetabolism - متابولیسم Respiratory exchange ratio - نسبت تبادل تنفسیarcuate nucleus - هسته قوسparaventricular nucleus - هسته پروژسترویکHypothalamus - هیپوتالاموس
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
In the present study we sought to investigate interactions between hypothalamic nitric oxide (NO) and ghrelin signaling on food intake and energy substrate utilization as measured by the respiratory exchange ratio (RER). Guide cannulae were unilaterally implanted in either the arcuate (ArcN) or paraventricular (PVN) nuclei of male Sprague-Dawley rats. Animals were pretreated with subcutaneous (2.5-10Â mg/kg/ml) or central (0-100Â pmol) N-nitro-l-Arginine methyl ester (l-NAME) followed by 50Â pmol of ghrelin administered into either the ArcN or PVN. Both l-NAME and ghrelin were microinjected at the onset of the active cycle and food intake and RER were assessed 2Â h postinjection. RER was measured as the ratio of the volume of carbon dioxide expelled relative to the volume of oxygen consumed (VCO2/VO2) using an open-circuit indirect calorimeter. Our results demonstrated that peripheral and central l-NAME pretreatment dose-dependently attenuated ghrelin induced increases in food intake and RER in either the ArcN or PVN. In fact the 100Â pmol dose largely reversed the metabolic effects of ghrelin in both anatomical regions. These findings suggest that ghrelin enhancement of food intake and carbohydrate oxidation in the rat ArcN and PVN is NO-dependent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 250, 1 September 2017, Pages 9-14
Journal: General and Comparative Endocrinology - Volume 250, 1 September 2017, Pages 9-14
نویسندگان
Shayan Abtahi, Aaisha Mirza, Erin Howell, Paul J. Currie,