کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5587782 | 1568860 | 2017 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of glucose and insulin administration on glucose transporter expression in the North Pacific spiny dogfish (Squalus suckleyi)
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of glucose and insulin administration on glucose transporter expression in the North Pacific spiny dogfish (Squalus suckleyi) Effects of glucose and insulin administration on glucose transporter expression in the North Pacific spiny dogfish (Squalus suckleyi)](/preview/png/5587782.png)
چکیده انگلیسی
Elasmobranchs (sharks, skates, and rays) are a primarily carnivorous group of fish, consuming few carbohydrates. Further, they tend to exhibit delayed responses to glucose and insulin administration in vivo relative to mammals, leading to a presumption of glucose-intolerance. To investigate the glucoregulatory capabilities of the spiny dogfish (Squalus suckleyi), plasma glucose concentration, muscle and liver glycogen content, and glucose transporter (glut1 and 4) mRNA levels were measured following intra-arterial administration of bovine insulin (10 ng kgâ1) or an approximate doubling of fasting plasma glucose concentration. Within 6 h, following glucose administration, approximately half of the introduced glucose load had been cleared, with control levels being restored by 24 h post-injection. It was determined that plasma clearance was due in part to increased uptake by the tissues as muscle and liver glycogen content increased significantly, correlating with an upregulation of glut mRNA levels. Following administration of bovine insulin, plasma glucose steadily decreased through 18 h before returning toward control levels. Observed decreases in plasma glucose following insulin injection were, however, relatively minor, and no increases in tissue glycogen content were observed. glut4 and glycogen synthase mRNA levels did significantly increase in the muscle in response to insulin, but no changes occurred in the liver. The responses observed mimic what occurs in mammals and teleosts, thus suggesting a conserved mechanism for glucose homeostasis in vertebrates and a high degree of glucose tolerance in these predominantly carnivorous fish.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 247, 1 June 2017, Pages 46-52
Journal: General and Comparative Endocrinology - Volume 247, 1 June 2017, Pages 46-52
نویسندگان
Courtney A. Deck, W. Gary Anderson, Patrick J. Walsh,