کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5589537 | 1569805 | 2017 | 47 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transcriptome analysis of IFM-specific actin and myosin nulls in Drosophila melanogaster unravels lesion-specific expression blueprints across muscle mutations
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کلمات کلیدی
IFMMyBP-CGCOSmyosin binding protein HRMAGEOSAMSignificance analysis of microarray - تجزیه و تحلیل اهمیت میکروارگانیسمMicroarray - ریزآرایهMyosin heavy chain - زنجیره سنگین میوزینIndirect flight muscles - عضلات پرواز غیر مستقیمMetabolism - متابولیسم MHC - مجموعه سازگاری بافتی اصلیHeat shock response - پاسخ شوک گرماImmune response - پاسخ یا واکنش ایمنیProteasome - پروتئازومmyosin binding protein C - پروتئین C اتصال مایوسینGene Expression Omnibus - ژن بیان Omnibus
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Muscle contraction is a highly fine-tuned process that requires the precise and timely construction of large protein sub-assemblies to form sarcomeres. Mutations in many genes encoding constituent proteins of this macromolecular machine result in defective functioning of the muscle tissue. However, the pathways underlying muscle degeneration, and manifestation of myopathy phenotypes are not well understood. In this study, we explored transcriptional alterations that ensue from the absence of the two major muscle proteins - myosin and actin - using the Drosophila indirect flight muscles. Our aim was to understand how the muscle tissue responds as a whole to the absence of either of the major scaffold proteins, whether the responses are generic to the tissue; or unique to the thick versus thin filament systems. Our results indicated that muscles respond by altering gene transcriptional levels in multiple systems active in muscle remodelling, protein degradation and heat shock responses. However, there were some responses that were filament-specific signatures of muscle degeneration, like immune responses, metabolic alterations and alterations in expression of muscle structural genes and mitochondrial ribosomal genes. These general and filament-specific changes in gene expression may be of relevance to human myopathies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 631, 5 October 2017, Pages 16-28
Journal: Gene - Volume 631, 5 October 2017, Pages 16-28
نویسندگان
Aditi Madan, Divesh Thimmaiya, Ari Franco-Cea, Mohammed Aiyaz, Prabodh Kumar, John C. Sparrow, Upendra Nongthomba,