کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5591808 | 1570644 | 2016 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology
ترجمه فارسی عنوان
حل رابطه همگام سازی تابع از طریق ژنومیک مقایسه ای از ماشین آلات غشای قاچاق و زیست شناسی سلول های انگلی
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کلمات کلیدی
SNAREVPSESCRTFunctional homologyParasite - انگلRab - ربEndomembrane - غشای غددendosomal sorting complexes required for transport - مجتمع های مرتب سازی آندوسومی برای حمل و نقل مورد نیاز استVacuolar protein sorting - مرتب سازی پروتئین Vacuolaradaptor protein - پروتئین آداپتورProtist - پروتستGenomics - ژنومیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
چکیده انگلیسی
With advances in DNA sequencing technology, it is increasingly common and tractable to informatically look for genes of interest in the genomic databases of parasitic organisms and infer cellular states. Assignment of a putative gene function based on homology to functionally characterized genes in other organisms, though powerful, relies on the implicit assumption of functional homology, i.e. that orthology indicates conserved function. Eukaryotes reveal a dazzling array of cellular features and structural organization, suggesting a concomitant diversity in their underlying molecular machinery. Significantly, examples of novel functions for pre-existing or new paralogues are not uncommon. Do these examples undermine the basic assumption of functional homology, especially in parasitic protists, which are often highly derived? Here we examine the extent to which functional homology exists between organisms spanning the eukaryotic lineage. By comparing membrane trafficking proteins between parasitic protists and traditional model organisms, where direct functional evidence is available, we find that function is indeed largely conserved between orthologues, albeit with significant adaptation arising from the unique biological features within each lineage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Biochemical Parasitology - Volume 209, Issues 1â2, SeptemberâOctober 2016, Pages 88-103
Journal: Molecular and Biochemical Parasitology - Volume 209, Issues 1â2, SeptemberâOctober 2016, Pages 88-103
نویسندگان
Christen M. Klinger, Inmaculada Ramirez-Macias, Emily K. Herman, Aaron P. Turkewitz, Mark C. Field, Joel B. Dacks,