کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5591863 | 1570702 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oligomeric proanthocyanidins attenuate airway inflammation in asthma by inhibiting dendritic cells maturation
ترجمه فارسی عنوان
پروانتوسیانیدین های اولیگومرین با القای مهار بلوغ سلول های دندریتی، التهاب هوا در آسم را کاهش می دهند
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کلمات کلیدی
DCscAMP responsive element modulatorcAMP responsive element-binding proteinCD86BMDCsMCHCREBOVAMFIAHROPCs - OPC هاAsthma - آسمOvalbumin - اوبلبومینinterleukin - اینترلوکینBALF - بافتcluster of differentiation - خوشه تمایزDendritic cells - سلول های دندریتیکbone marrow derived dendritic cells - سلولهای دندریتیک مشتق شده از مغز استخوانmedian fluorescence intensity - شدت فلورسانس متوسطMethacholine - متاکولینAirway hyperresponsiveness - پاسخگویی فوریOligomeric proanthocyanidins - پروانتوسایانیدینهای الیگومریCREm - کرم رنگ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
چکیده انگلیسی
To date, although a promising anti-inflammatory activity of oligomeric proanthocyanidins (OPCs) has been observed in asthma, the mechanism responsible for these immunomodulatory properties remains obscure. Dendritic cells (DCs) that reside in the airway have been widely perceived as an important contributor to asthma. Our study was to demonstrate OPCs' effects on maturation and immunoregulation of pulmonary CD11c+ dendritic cells (DCs). BALB/c mice were exposed to ovalbumin (OVA) to induce murine model of asthma. In addition, pulmonary DCs and bone marrow-derived DCs (BMDCs) cultures were used to evaluate impacts of OPCs on DCs function. The results obtained here indicated that OPCs treatment dramatically reduced airway inflammation, such as the infiltration of inflammatory cells and the levels of allergen-specific serum IgE and Th2 cytokines. The expression of co-stimulatory molecules especially CD86 distributed on pulmonary DCs and bone marrow-derived DCs (BMDCs) also markedly declined. The phosphorylation of cAMP responsive element-binding protein (CREB) was significantly inhibited while no changes were observed in the expression of cAMP responsive element modulator (CREM). By transferring BMDCs into the airways of naïve mice, we found that OPCs-treated DCs (DCÂ +Â OVAÂ +Â OPC) were much less potent in promoting CD4+ T cells proliferation than OVA-pulsed DCs (DCÂ +Â OVA), followed by the ameliorated eosinophilic inflammation in airway. Our findings tailor a novel profile of OPCs in the regulation of DCs function, shedding new light on the therapeutic potential of OPCs in asthma management.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 91, November 2017, Pages 209-217
Journal: Molecular Immunology - Volume 91, November 2017, Pages 209-217
نویسندگان
Yeshan Li, Qijun Yu, Wenxue Zhao, Jiaxiang Zhang, Wentao Liu, Mao Huang, Xiaoning Zeng,