کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5591955 1570709 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complement in basic processes of the cell
ترجمه فارسی عنوان
تکمیل در فرایندهای اولیه سلول
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
چکیده انگلیسی


- Extrahepatic and autocrine complement influence their local behavior.
- Complotypes can tilt complement activation toward inflammation.
- Extracellular complement regulates dendritic cell differentiation.
- Extracellular complement regulates B cell function through CR and TLR crosstalk.
- Intracellular C3 and C5 cleavage have crucial autocrine roles in T-cell function.

The complement system is reemerging in the last few years not only as key element of innate immunity against pathogens, but also as a main regulator of local adaptive responses, affecting dendritic cells as well as T and B lymphocytes. We review data showing that leucocytes are capable of significant autocrine synthesis of complement proteins, and express a large range of complement receptors, which in turn regulate their differentiation and effector functions while cross talking with other innate receptors such as Toll-like receptors. Other unconventional roles of complement proteins are reviewed, including their impact in non-leukocytes and their intracellular cleavage by vesicular proteases, which generate critical cues required for T cell function. Thus, leucocytes are very much aware of complement-derived information, both extracellular and intracellular, to elaborate their responses, offering rich avenues for therapeutic intervention and new hypothesis for conserved major histocompatibility complex complotypes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 84, April 2017, Pages 10-16
نویسندگان
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