کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5592208 | 1570714 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tuberculosis-sensitized monocytes sustain immune response of interleukin-37
ترجمه فارسی عنوان
مونوسیت های حساس شده سلول ها ایمنی واکنش اینترلوکین 37 را حفظ می کنند
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
چکیده انگلیسی
Roles of human IL-37 in infections remain poorly characterized. Although plasma IL-37 is elevated in patients with tuberculosis (TB), IL-37 source and immune correlate in TB have not been investigated. It is also unknown whether and how TB can influence the ability of immune cells to mount innate responses of IL-37 and pre-inflammatory cytokines. Here, we demonstrated that IL-37b-producing monocytes coincided with a source of elevated plasma IL-37b in TB patients. While IL-37b production in TB was associated with prolonged/complicated TB, TB burdens and inflammatory reactions, it negatively correlated with immune responses of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α or IL-10. Interestingly, mycobacterial re-infection of monocytes from TB patients, but not healthy BCG-vaccinated controls, enhanced or sustained IL-37b production by cultured monocytes. TB-sensitized monocytes from TB patients mounted more robust immune responses of IL-37b than those of pre-inflammatory cytokines during mycobacterial re-infection in culture. Our data represent new findings in terms of IL-37b responses, immune correlates and potential mechanisms in TB patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 79, November 2016, Pages 14-21
Journal: Molecular Immunology - Volume 79, November 2016, Pages 14-21
نویسندگان
Jun-Ai Zhang, Gan-Bin Liu, Bi-Ying Zheng, Yuan-Bin Lu, Yu-Chi Gao, Xiao-Zhen Cai, You-Chao Dai, Shi-Yan Yu, Yan Jia, Chen Chen, Ze-Gang Zhuang, Xin Wang, Wan-Dang Wang, Xiao-Xia Fu, Lai-Long Yi, Ling Shen, Zheng W. Chen, Jun-Fa Dr.,