کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5593547 1571137 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of directed photic stimulation of the pineal on experimental Parkinson's disease
ترجمه فارسی عنوان
اثر تحریک طوفان هدایت مفصل انگشت در بیماری پارکینسون تجربی
کلمات کلیدی
پنبه ای بیماری پارکینسون، سبک، ملانوسیت، دوپامین، ملاتونین، ملانین، دوران کودکی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
چکیده انگلیسی
The role of the circadian system in Parkinson's disease (PD) is a topic of increasing scientific interest. This has emerged from recent studies demonstrating an altered response of PD patients to treatment in relation to the phase of the light/dark cycle and from other work defining the functional significance of melanocytes in PD: a cell type that the nigro-striatal dopamine (NSD) system and circadian system both contain. The present study was undertaken to determine the sensitivity of the pineal, as the final common pathway of the circadian system, to light delivered directly to the pineal via surgical implantation of LEDs. Direct photic stimulation of the pineal altered the course of experimental PD while anatomical controls receiving stimulation of the frontal cortex exhibited a negative impact on the course of recovery of these animals. These effects were closely linked to the phase of the light/dark cycle. The present results suggest that while pineal photoreceptors are regarded as vestigial, functional photo-reactivity of the pineal remains. It is inferred that melanocytes are the active cells responsible for the observed effect since they remain functionally intact in mammalian pineal even though pineal photoreceptors are functionally inert. Although the stimuli applied in the present study may be regarded as artificial this study demonstrates that brain parenchyma remains differentially reactive to direct light exposure and presents a novel mechanism in circadian structures that needs to be explored.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 182, 1 December 2017, Pages 1-9
نویسندگان
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