کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5593898 1571143 2017 41 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex differences in obesity: X chromosome dosage as a risk factor for increased food intake, adiposity and co-morbidities
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Sex differences in obesity: X chromosome dosage as a risk factor for increased food intake, adiposity and co-morbidities
چکیده انگلیسی
Obesity is a world-wide problem, and a risk factor for cardiovascular disease, diabetes, cancer and other diseases. It is well established that sex differences influence fat storage. Males and females exhibit differences in anatomical fat distribution, utilization of fat stores, levels of adipose tissue-derived hormones, and obesity co-morbidities. The basis for these sex differences may be parsed into the effects of male vs. female gonadal hormones and the effects of XX vs. XY chromosome complement. Studies employing mouse models that allow the distinction of gonadal from chromosomal effects have revealed that X chromosome dosage influences food intake, which in turn affects adiposity and the occurrence of adverse metabolic conditions such as hyperinsulinemia, hyperlipidemia, and fatty liver. The identification of X chromosome dosage as a player in the behavior and physiology related to obesity suggests novel molecular mechanisms that may underlie sex differences in obesity and metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 176, 1 July 2017, Pages 174-182
نویسندگان
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