کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5593977 | 1571151 | 2017 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of low frequency electrical stimulation on seizure-induced short- and long-term impairments in learning and memory in rats
ترجمه فارسی عنوان
تأثیر تحریک الکتریکی بر روی تخریب های کوتاه مدت و بلند مدت ناشی از تشنج در یادگیری و حافظه در موش صحرایی
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کلمات کلیدی
صرع، یادگیری و حافظه، تحریک با فرکانس پایین، کینگینگ،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
چکیده انگلیسی
Kindled seizures can impair learning and memory. In the present study the effect of low-frequency electrical stimulation (LFS) on kindled seizure-induced impairment in spatial learning and memory was investigated and followed up to one month. Animals were kindled by electrical stimulation of hippocampal CA1 area in a semi-rapid manner (12 stimulations per day). One group of animals received four trials of LFS at 30Â s, 6Â h, 24Â h, and 30Â h following the last kindling stimulation. Each LFS trial was consisted of 4 packages at 5Â min intervals. Each package contained 200 monophasic square wave pulses of 0.1Â ms duration at 1Â Hz. The Open field, Morris water maze, and novel object recognition tests were done 48Â h, 1Â week, 2Â weeks, and one month after the last kindling stimulation respectively. Kindled animals showed a significant impairment in learning and memory compared to control rats. LFS decreased the kindling-induced learning and memory impairments at 24Â h and one week following its application, but not at 2Â week or 1Â month after kindling. In the group of animals that received the same 4 trials of LFS again one week following the last kindling stimulation, the improving effect of LFS was observed even after one month. Obtained results showed that application of LFS in fully kindled animals has a long-term improving effect on spatial learning and memory. This effect can remain for a long duration (one month in this study) by increasing the number of applied LFS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 168, 1 January 2017, Pages 112-121
Journal: Physiology & Behavior - Volume 168, 1 January 2017, Pages 112-121
نویسندگان
Khadijeh Esmaeilpour, Vahid Sheibani, Mohammad Shabani, Javad Mirnajafi-Zadeh,