کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5600936 | 1405304 | 2017 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung
ترجمه فارسی عنوان
پیشرفت در تشخیص و مدیریت تومورهای نوروآندوکرین به خوبی تشخیص داده شده و متوسط است.
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کلمات کلیدی
ENETSSSTRNCCNLCNECPFs - PF هاprogression-free survival - بقا بدون پیشرفتSCLC - بگذارندNeuroendocrine tumor - تومور نورو اندوکرینPulmonary neuroendocrine tumors - تومورهای عصبی عضلانی ریهNET - خالصWorld Health Organization - سازمان بهداشت جهانیNational Comprehensive Cancer Network - شبکه جامع سرطانی ملیAtypical carcinoid - کارسینوئید آتیپیکTypical carcinoid - کارسینوئید معمولیSmall cell lung carcinoma - کارسینوم ریه کوچک سلولیLarge cell neuroendocrine carcinoma - کارسینوم عصبی عصبی سلولی بزرگWHO - کهSomatostatin receptor - گیرنده سوماتوستاتین
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Neuroendocrine tumors (NETs) are a rare, heterogeneous group of malignancies that arise from neuroendocrine cells throughout the body, with the lungs and GI tract being the most common sites of origin. Despite increasing incidence, awareness of lung NETs remains low among thoracic specialists who are often involved in the assessment and early treatment of these patients. Successful treatment requires accurate and timely diagnosis; however, classification can be challenging, particularly for well-differentiated and intermediate-differentiated lung NET types (typical carcinoids [TC] and atypical carcinoids [AC]). Diagnosis and management of lung NETs are further complicated by the nonspecificity of symptoms, variable natural history, and lack of high-level clinical evidence; a multidisciplinary approach is required, which has been shown to improve prognosis. Currently, surgery remains the only curative option for TC/AC. Inconsistencies between guideline recommendations for systemic therapies, especially for chemotherapy, result in a lack of consensus on a standardized treatment for unresectable disease. Recent data from the Phase III RAD001 in Advanced Neuroendocrine Tumors, Fourth Trial (RADIANT-4), which contained a large population of patients with advanced, well-differentiated, nonfunctional lung NETs in addition to those with GI NETs, found a reduced risk of disease progression and death with everolimus compared with placebo, leading to US approval of everolimus in these patient populations. This study is the first high-level therapeutic evidence in patients with TC/AC, and everolimus is currently the only agent approved for treatment of TC/AC. Increased awareness, prompt diagnosis, and additional adequately powered controlled clinical trials of patients with well-differentiated and intermediate-differentiated lung NETs are needed to further improve evidence-based care.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 151, Issue 5, May 2017, Pages 1141-1146
Journal: Chest - Volume 151, Issue 5, May 2017, Pages 1141-1146
نویسندگان
Edward M. MD,