کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5605538 1576120 2017 60 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Towards the standardization of stem cell therapy studies for ischemic heart diseases: Bridging the gap between animal models and the clinical setting
ترجمه فارسی عنوان
به سوی استاندارد سازی مطالعات درمان با سلول های بنیادی برای بیماری های قلبی ایسکمی: برطرف کردن شکاف بین مدل های حیوانی و محیط بالینی
کلمات کلیدی
درمان با سلول های بنیادی، داروهای احیا کننده، مدل حیوانی، بیماری های قلبی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Today there is an increasing demand for heart transplantations for patients diagnosed with heart failure. Though, shortage of donors as well as the large number of ineligible patients hurdle such treatment option. This, in addition to the considerable number of transplant rejections, has driven the clinical research towards the field of regenerative medicine. Nonetheless, to date, several stem cell therapies tested in animal models fall by the wayside and when they meet the criteria to clinical trials, subjects often exhibit modest improvements. A main issue slowing down the admission of such therapies in the domain of human trials is the lack of protocol standardization between research groups, which hampers comparison between different approaches as well as the lack of thought regarding the clinical translation. In this sense, given the large amount of reports on stem cell therapy studies in animal models reported in the last 3 years, we sought to evaluate their advantages and limitations towards the clinical setting and provide some suggestions for the forthcoming investigations. We expect, with this review, to start a new paradigm on regenerative medicine, by evoking the debate on how to plan novel stem cell therapy studies with animal models in order to achieve more consistent scientific production and accelerate the admission of stem cell therapies in the clinical setting.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 228, 1 February 2017, Pages 465-480
نویسندگان
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