کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5605615 | 1576120 | 2017 | 6 صفحه PDF | دانلود رایگان |
ObjectiveCXCR4 signaling contributes to the development and progression of neovascularization. The objective of this study was to investigate whether CXCR4 expression in peripheral CD34 + cells associated with the coronary collateralization (CC) in patients with chronic total coronary occlusion (CTO).Methods and resultsWe measured CXCR4 expression in peripheral CD34 + cells and assessed its relation with CC in a nested case-control study including 78 cases and 78 matched controls aged 38-69 years, assessed in January 2011 to December 2012 and with at least 1 year of follow-up before the index date. Cases were defined as good coronary collateralization (GCC) according to the Rentrop scoring system (Rentrop score of 2 or 3); for each case, one age-matched control with poor coronary collateralization (PCC) (Rentrop score 0 or 1) was randomly selected from the study participants. Demographic, biochemical, and angiographic variables were collected. In multivariate analysis, the OR (95% CI) of CXCR4 expression was 0.018 (0.017 to 0.020) in patients with GCC versus PCC. Independent effect of CXCR4 expression on CC was (OR 0.012, 95% CI 0.010-0.014) when adjusted for other variables. A nonlinear relationship between CXCR4 expression and CC was observed. The CC degree increased when CXCR4 expression exceeded the turning point (30%) (OR 0.025, 95% CI 0.022-0.028; p < 0.001). When the CXCR4 expression exceeded 75%, increased CXCR4 level could not promoted CC (OR 0.000, 95% CI 0.008-0.007; p = 0.974).ConclusionIncreased CXCR4 level in peripheral CD34 + cells was associated with GCC in patients with CTO.
Journal: International Journal of Cardiology - Volume 228, 1 February 2017, Pages 501-506