Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release

The incidences of peripheral arterial diseases and aortic abdominal aneurysms are steadily increasing because of arteriosclerosis in the elderly. The postoperative morbidity of infrarenal vascular operations is closely linked to or accompanied by ischemia-reperfusion-induced injury and inflammation. This study provides a novel approach for alleviating acute lung injury induced by infrarenal aortic cross-clamping, which is a common procedure during infrarenal vascular operations. Given that hydrogen sulfide could protect multiple organs against several risk events, the results warrant further investigation by using GYY4137 in preventing acute lung injury during infrarenal vascular surgical interventions.