Clearance of matrix metalloproteinase-9 is dependent on low-density lipoprotein receptor-related protein-1 expression downregulated by microRNA-205 in human abdominal aortic aneurysm

Low-density lipoprotein receptor-related protein-1 (LRP1) has been suggested to be a lead gene for abdominal aortic aneurysm (AAA) pathogenesis. Its involvement in AAA is still a mystery, however. This study highlighted the importance of tight regulation of LRP1 expression mediated by microRNA-205 for determination of vascular wall integrity through monitoring the pericellular matrix metalloproteinase-9 level. The manipulation of LRP1 expression by microRNA-205 inhibitor may become a new therapeutic prevention of AAA in the future.