Prevention of perioperative vascular prosthetic infection with a novel triple antimicrobial-bonded arterial graft

This novel vascular graft was developed to combat devastating periprosthetic aortic infections associated with major arterial reconstructive surgery. When the graft's ability to provide extended protection has been verified, the device could be recommended for in situ replacement of infected grafts and possibly for routine primary implantation-especially in immunocompromised patients and those with heavily contaminated fields such as perforating body cavity wounds, hostile abdomen, and redo procedures. The graft's preventive effects against Staphylococcus aureus could be extended for prevention of other, less common causes of perioperative infections, such as Pseudomonas aeruginosa, other members of the Staphylococcus family, and fungi.