Coadministration of adipose-derived stem cells and control-released basic fibroblast growth factor facilitates angiogenesis in a murine ischemic hind limb model

Previous studies have shown that even single administration of either autologous adipose-derived stem cells (ASCs) or control-released basic fibroblast growth factor sustained with a gelatin hydrogel into the ischemic lower extremities improves blood supply of the lower legs and promotes eventual wound healing clinically. In this study, we showed that coadministration of ASCs and control-released basic fibroblast growth factor facilitate angiogenesis as evidenced by higher secretion of angiogenic growth factors from ASCs, increase of the vascular density and caliber, and thickness of vessel walls, suggesting that coadministration might be expected to contribute to therapeutic angiogenesis more effectively in clinical situations.