Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase

To date, despite a large number of clinical trials, no strategy appears effective in improving long-term vein graft patency. Eph-B4 activity regulates vein graft adaptation, and this study shows that Eph-B4 stimulates endothelial nitric oxide synthase (eNOS) phosphorylation, suggesting that Eph-B4 activity during vein graft adaptation is mediated by eNOS. Modulation of eNOS activity may provide a potential new therapeutic target to improve vein graft patency.