An endovascular model of ischemic myopathy from peripheral arterial disease

Peripheral arterial disease (PAD) is a pandemic in need of novel pharmaceutical and regenerative medicine treatments. However, the clinical testing of novel therapies is best performed after dosing and delivery strategies have been identified in preclinical models. Unfortunately, there is not a suitable preclinical model of PAD. Here, we characterize a novel porcine model of PAD that delivers ischemic myopathy to the affected limb through sustained depressions in perfusion. The objective of this study was to create and to describe a novel, endovascular large animal model of PAD that may be useful in the testing of new pharmaceutical and cellular therapies for PAD.