Platelet-derived factor V promotes angiogenesis in a mouse hind limb ischemia model

Platelets and the fibrinolytic system contain many regulators of angiogenesis. Studying the specific roles of individual hemostatic proteins in angiogenesis could lead to novel therapeutic approaches by targeting the angiogenesis functions of the hemostatic proteins. However, the roles of factor V (FV) in angiogenesis have not been reported. This study suggests that platelet-derived FV has an important role in angiogenesis. The stimulation could be partially associated with thrombin generation due to platelet-derived FV.