Angiogenic properties of human placenta-derived adherent cells and efficacy in hindlimb ischemia

Peripheral arterial disease with diabetic foot ulcer is a major complication in patients with diabetes and is estimated to lead to ∼80,000 lower extremity amputations each year. A significant need exists for new treatment options that will promote revascularization and healing of damaged tissue. This report discusses the angiogenic and tissue reparative properties of PDA-002, a culture-expanded mesenchymal-like cell population derived from human placenta that is currently in clinical trials for peripheral arterial disease with diabetic foot ulcer (NCT01859117).