کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5618676 1406031 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The endogenous preproglucagon system is not essential for gut growth homeostasis in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
پیش نمایش صفحه اول مقاله
The endogenous preproglucagon system is not essential for gut growth homeostasis in mice
چکیده انگلیسی
The present study indicates that the endogenous preproglucagon system, exemplified by the entire GCG gene and the receptors for GLP-1 and GLP-2, does not play a major role in normal gut development in the mouse. Furthermore, elevation in local intestinal and circulating levels of GLP-1 and GLP-2 achieved after VSG has limited impact on intestinal morphometry. Hence, although exogenous treatment with GLP-1 and GLP-2 analogs enhances gut growth, the contributions of endogenously-secreted GLP-1 and GLP-2 to gut growth may be more modest and highly context-dependent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Metabolism - Volume 6, Issue 7, July 2017, Pages 681-692
نویسندگان
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