کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5619 | 406 | 2015 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Microstructured dextran hydrogels for burst-free sustained release of PEGylated protein drugs Microstructured dextran hydrogels for burst-free sustained release of PEGylated protein drugs](/preview/png/5619.png)
Hydrogels have gained significant attention as ideal delivery vehicles for protein drugs. However, the use of hydrogels for protein delivery has been restricted because their porous structures inevitably cause a premature leakage of encapsulated proteins. Here, we report a simple yet effective approach to regulate the protein release kinetics of hydrogels through the creation of microstructures, which serve as a reservoir, releasing their payloads in a controlled manner. Microstructured dextran hydrogels enable burst-free sustained release of PEGylated interferon over 3 months without compromising its bioactivity. These hydrogels substantially extend the circulation half-life of PEGylated interferon, allowing for less frequent dosing in a humanized mouse model of hepatitis C. The present approach opens up possibilities for the development of sustained protein delivery systems for a broad range of pharmaceutical and biomedical applications.
Journal: Biomaterials - Volume 63, September 2015, Pages 146–157