Total oxidative and anti-oxidative status, and ADAMTS-12 levels in placenta previa and early-onset severe preeclampsia

- Placenta previa and preeclampsia are very important causes of maternal death and morbidity.
- There is an inverse relation between placenta previa and preeclampsia.
- Oxidative stress plays an important role in the pathophysiology of preeclampsia.

AimThis study was carried out due to the discussions in the literature stating that the inverse association between placenta previa (PP) and preeclampsia (PE). The aim of this study was to determine whether total antioxidant status (TAS), and total oxidant status (TOS) and ADAMTS-12 levels differ among early-onset (<34th gestational week) severe PE (EOS-PE), PP and uncomplicated pregnancies.MethodsIn this case-control study, serum samples obtained from 26 pregnant with EOS-PE, 31 pregnant with PP, and 32 healthy patients with uncomplicated pregnancies (control group).ResultsTOS levels were significantly higher in the EOS-PE than in the control group and PP groups (p = 0.002, p = 0.05, respectively). TAS levels were significantly lower in the EOS-PE than in the control (p < 0.001). Although TAS levels were lower in the EOS-PE group than in the PP group, the differences were not statistically significant (p = 0.09). There were no significant differences in the ADAMTS-12 levels of the groups.DiscussionThe data in this study suggested that the balance between oxidative and anti-oxidative substances were comparable and normal in pregnancies complicated by PP when compared to normal pregnancies without placentation abnormality. In support of this, we encountered no case with PE and fetal growth restriction in our study groups suggesting normal placental angiogenesis. Contrarily, EOS-PE was associated with decreased TAS and increased TOS levels in the maternal serum.