کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5626331 | 1406316 | 2017 | 7 صفحه PDF | دانلود رایگان |
ObjectivePreterm infants are at high risk for developmental delay, epilepsy, and autism spectrum disorders. Some reports have described associations between these conditions and gamma-aminobutyric acid (GABA) dysfunction; however, no study has evaluated temporal changes in GABA in preterm infants. Therefore, we assessed temporal changes in brain metabolites including GABA using single-voxel 3-Tesla (T) proton magnetic resonance spectroscopy (1H-MRS) in preterm infants with normal development.MethodsWe performed 3T 1H-MRS at 37-46 postmenstrual weeks (PMWs, period A) and 64-73 PMWs (period B). GABA was assessed with the MEGA-PRESS method. N-acetyl aspartate (NAA), glutamate-glutamine complex (Glx), creatine (Cr), choline (Cho), and myo-inositol (Ins) were assessed with the PRESS method. Metabolite concentrations were automatically calculated using LCModel.ResultsData were collected from 20 preterm infants for periods A and B (medians [ranges], 30 [24-34] gestational weeks, 1281 [486-2030] g birth weight). GABA/Cr ratio decreased significantly in period B (p = 0.03), but there was no significant difference in GABA/Cho ratios (p = 0.58) between the two periods. In period B, NAA/Cr, Glx/Cr, NAA/Cho, and Glx/Cho ratios were significantly increased (p < 0.01), whereas Cho/Cr, Ins/Cr, and Ins/Cho ratios were significantly decreased (p < 0.01). There was no significant difference for GABA or Cho concentrations (p = 0.52, p = 0.22, respectively). NAA, Glx, and Cr concentrations were significantly increased (p < 0.01), whereas Ins was significantly decreased (p < 0.01).ConclusionsOur results provide new information on normative values of brain metabolites in preterm infants.
Journal: Brain and Development - Volume 39, Issue 3, March 2017, Pages 196-202