کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5626331 1406316 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleTemporal brain metabolite changes in preterm infants with normal development
ترجمه فارسی عنوان
مقاله اصلی تغییرات متابولیت مغزی در نوزادان نارس با توسعه طبیعی است
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی

ObjectivePreterm infants are at high risk for developmental delay, epilepsy, and autism spectrum disorders. Some reports have described associations between these conditions and gamma-aminobutyric acid (GABA) dysfunction; however, no study has evaluated temporal changes in GABA in preterm infants. Therefore, we assessed temporal changes in brain metabolites including GABA using single-voxel 3-Tesla (T) proton magnetic resonance spectroscopy (1H-MRS) in preterm infants with normal development.MethodsWe performed 3T 1H-MRS at 37-46 postmenstrual weeks (PMWs, period A) and 64-73 PMWs (period B). GABA was assessed with the MEGA-PRESS method. N-acetyl aspartate (NAA), glutamate-glutamine complex (Glx), creatine (Cr), choline (Cho), and myo-inositol (Ins) were assessed with the PRESS method. Metabolite concentrations were automatically calculated using LCModel.ResultsData were collected from 20 preterm infants for periods A and B (medians [ranges], 30 [24-34] gestational weeks, 1281 [486-2030] g birth weight). GABA/Cr ratio decreased significantly in period B (p = 0.03), but there was no significant difference in GABA/Cho ratios (p = 0.58) between the two periods. In period B, NAA/Cr, Glx/Cr, NAA/Cho, and Glx/Cho ratios were significantly increased (p < 0.01), whereas Cho/Cr, Ins/Cr, and Ins/Cho ratios were significantly decreased (p < 0.01). There was no significant difference for GABA or Cho concentrations (p = 0.52, p = 0.22, respectively). NAA, Glx, and Cr concentrations were significantly increased (p < 0.01), whereas Ins was significantly decreased (p < 0.01).ConclusionsOur results provide new information on normative values of brain metabolites in preterm infants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Development - Volume 39, Issue 3, March 2017, Pages 196-202
نویسندگان
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