کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5626695 1406326 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long term clinical and neurophysiological effects of cerebellar transcranial direct current stimulation in patients with neurodegenerative ataxia
ترجمه فارسی عنوان
اثرات بالینی و عصبی فیزیولوژیکی تحریک جریان مستقیم ترانس کرانانی مخچه در بیماران مبتلا به آتاکسی نئوژنیک
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


- This study investigated the effects of repeated sessions of cerebellar tDCS in patients with ataxia.
- The findings demonstrated that anodal tDCS improved clinical scores compared to sham stimulation.
- Cerebellar tDCS restored physiological cerebellar brain inhibition pathways.
- These novel findings provide a rationale for the therapeutic application of cerebellar tDCS in patients with ataxia.

BackgroundNeurodegenerative cerebellar ataxias represent a group of disabling disorders for which we currently lack effective therapies. Cerebellar transcranial direct current stimulation (tDCS) is a non-invasive technique, which has been demonstrated to modulate cerebellar excitability and improve symptoms in patients with cerebellar ataxias.ObjectiveThe present study investigated whether a two-weeks' treatment with cerebellar anodal tDCS could improve symptoms in patients with neurodegenerative cerebellar ataxia and could modulate cerebello-motor connectivity, at short and long term.MethodsWe performed a double-blind, randomized, sham controlled trial with cerebellar tDCS (5 days/week for 2 weeks) in twenty patients with ataxia. Each patient underwent a clinical evaluation pre- and post-anodal tDCS or sham stimulation. A follow-up evaluation was performed at one and three months. Cerebello-motor connectivity was evaluated using transcranial magnetic stimulation (TMS) at baseline and at follow-up.ResultsPatients who underwent anodal tDCS showed a significant improvement in all performance scores (scale for the assessment and rating of ataxia, international cooperative ataxia rating scale, 9-hole peg test, 8-m walking time) and in cerebellar brain inhibition compared to patients who underwent sham stimulation.ConclusionsA two-weeks' treatment with anodal cerebellar tDCS improves symptoms in patients with ataxia and restores physiological cerebellar brain inhibition pathways. Cerebellar tDCS might represent a promising future therapeutic and rehabilitative approach in patients with neurodegenerative ataxia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Stimulation - Volume 10, Issue 2, March–April 2017, Pages 242-250
نویسندگان
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