کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627834 1406356 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sleep-related modifications of EEG connectivity in the sensory-motor networks in Huntington Disease: An eLORETA study and review of the literature
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Sleep-related modifications of EEG connectivity in the sensory-motor networks in Huntington Disease: An eLORETA study and review of the literature
چکیده انگلیسی


- We investigated EEG connectivity during wake and sleep, in patients with Huntington Disease (HD).
- HD is related with EEG connectivity alterations in the sensory-motor network during wake and sleep.
- Our results may reflect the expression of a compensatory mechanism.

ObjectiveTo evaluate EEG functional connectivity in the sensory-motor network, during wake and sleep, in patients with Huntington Disease (HD).Methods23 patients with HD and 23 age- and sex-matched healthy controls were enrolled. EEG connectivity analysis was performed by means of exact Low Resolution Electric Tomography (eLORETA).ResultsIn wake, HD patients showed an increase of delta lagged phase synchronization (T = 3.60; p < 0.05) among Broadman's Areas (BA) 6-8 bilaterally; right BA 6-8 and right BA 1-2-3; left BA 1-2-3 and left BA 4. In NREM, HD patients showed an increase of delta lagged phase synchronization (T = 3.56; p < 0.05) among left BA 1-2-3 and right BA 6-8. In REM, HD patients showed an increase of lagged phase synchronization (T = 3.60; p < 0.05) among the BA 6-8 bilaterally (delta band); left BA 1-2-3 and right BA 1-2-3 (theta); left BA 1-2-3 and right BA 4 (theta); left BA 1-2-3 and right BA 1-2-3 (alpha).ConclusionsOur results may reflect an abnormal function of the motor areas or an effort to counterbalance the pathological motor output.SignificanceOur results may help to understand the pathophysiology of sleep-related movement disorders in Huntington's Disease, and to define therapeutically strategies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 128, Issue 7, July 2017, Pages 1354-1363
نویسندگان
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