کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627868 1406357 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detection
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Phenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detection
چکیده انگلیسی


- Phenobarbital reduces both amplitude and propagation of neonatal seizures.
- These changes may help to explain electroclinical uncoupling.
- The performance of our seizure detection algorithm was unaffected.

ObjectivePhenobarbital increases electroclinical uncoupling and our preliminary observations suggest it may also affect electrographic seizure morphology. This may alter the performance of a novel seizure detection algorithm (SDA) developed by our group.The objectives of this study were to compare the morphology of seizures before and after phenobarbital administration in neonates and to determine the effect of any changes on automated seizure detection rates.MethodsThe EEGs of 18 term neonates with seizures both pre- and post-phenobarbital (524 seizures) administration were studied. Ten features of seizures were manually quantified and summary measures for each neonate were statistically compared between pre- and post-phenobarbital seizures. SDA seizure detection rates were also compared.ResultsPost-phenobarbital seizures showed significantly lower amplitude (p < 0.001) and involved fewer EEG channels at the peak of seizure (p < 0.05). No other features or SDA detection rates showed a statistical difference.ConclusionThese findings show that phenobarbital reduces both the amplitude and propagation of seizures which may help to explain electroclinical uncoupling of seizures. The seizure detection rate of the algorithm was unaffected by these changes.SignificanceThe results suggest that users should not need to adjust the SDA sensitivity threshold after phenobarbital administration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 127, Issue 10, October 2016, Pages 3343-3350
نویسندگان
, , , , , ,