کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5628707 1579887 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered language network in benign childhood epilepsy patients with spikes from non-dominant side: A resting-state fMRI study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Altered language network in benign childhood epilepsy patients with spikes from non-dominant side: A resting-state fMRI study
چکیده انگلیسی


- Focus on BECTS children with spikes from the non-dominant side.
- Increased positive functional connectivity within the Broca's region was found.
- Increases in BA8, bilateral insula, and anterior and posterior cingulate.
- No decrease was detected.
- Normal language network is disrupted in BETCS children.

Benign childhood epilepsy with centrotemporal spikes (BECTS) is one of the most common childhood epilepsy syndromes, and language deficits associated with BECTS have become a hot topic. This study investigated alterations of the language network in BECTS children with spikes from the non-dominant side in comparison with healthy controls. Twenty-three children with BECTS and 20 age-matched healthy controls were enrolled. Region of interest −based whole brain functional connectivity analysis was used to identify the potential differences in the functional connectivity of the Broca's area between the two groups. Increased positive functional connectivity within the Broca's region was detected mainly at the left superior frontal gyrus (Brodmann area 8), bilateral insula, and anterior and posterior cingulate in the BECTS group. No regions showed significantly decreased connection in the BECTS patients compared to the controls. This study suggested alterations in the language network that was related with the Broca's area in children with BECTS from the non-dominant side. Further studies with longitudinal assessments from the perceptive of functional neuroimaging are needed to illustrate the dynamic course of language development and corresponding neuroimaging evidence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 136, October 2017, Pages 109-114
نویسندگان
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