کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5628726 | 1579888 | 2017 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Features of amygdala in patients with mesial temporal lobe epilepsy and hippocampal sclerosis: An MRI volumetric and histopathological study Features of amygdala in patients with mesial temporal lobe epilepsy and hippocampal sclerosis: An MRI volumetric and histopathological study](/preview/png/5628726.png)
- We studied the amygdala of 26 temporal lobe epilepsy patients.
- Amygdala was investigated radiologically and pathologically.
- Amygdala with hippocampal sclerosis (HS) was more damaged than those without HS.
- Hippocampus features were not parallel to those of the amygdala.
ObjectiveIt is well-known that there is a correlation between the neuropathological grade of hippocampal sclerosis (HS) and neuroradiological atrophy of the hippocampus in mesial temporal lobe epilepsy (mTLE) patients. However, there is no strict definition or criterion regarding neuron loss and atrophy of the amygdala neighboring the hippocampus. We examined the relationship between HS and neuronal loss in the amygdala.Materials and methodsNineteen mTLE patients with neuropathological proof of HS were assigned to Group A, while seven mTLE patients without HS were assigned to Group B. We used FreeSurfer software to measure amygdala volume automatically based on pre-operation magnetic resonance images. Neurons observed using Klüver-Barrera (KB) staining in resected amygdala tissue were counted. and the extent of immunostaining with stress marker antibodies was semiquantitatively evaluated.ResultsThere was no significant difference in amygdala volume between the two groups (Group A: 1.41 ± 0.24; Group B: 1.41 ± 0.29 cm3; p = 0.98), nor in the neuron cellularity of resected amygdala specimens (Group A: 3.98 ± 0.97; Group B: 3.67 ± 0.67 10 Ã â4 number of neurons/μm2; p = 0.40). However, the HSP70 level, representing acute stress against epilepsy, in Group A patients was significantly larger than that in Group B. There was no significant difference in the level of Bcl-2, which is known as a protein that inhibits cell death, between the two groups.ConclusionsNeuronal loss and volume loss in the amygdala may not necessarily follow hippocampal sclerosis. From the analysis of stress proteins, epileptic attacks are as likely to damage the amygdala as the hippocampus but do not lead to neuronal death in the amygdala.
Journal: Epilepsy Research - Volume 135, September 2017, Pages 50-55