کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5628928 | 1580002 | 2017 | 9 صفحه PDF | دانلود رایگان |
- Selection of children for DBS must include consideration of the target for electrode placement.
- Whilst the GPi is the commonest target for electrode placement, other nuclei may be more appropriate for a particular child.
- An ABC for DBS is proposed: Appropriate Child selected; Best nuclei chosen for electrode insertion; Correct position within that nucleus.
Deep brain stimulation (DBS) has become a mainstay of dystonia management in adulthood. Typically targeting electrode placement in the GPi, sustained improvement in dystonic symptoms are anticipated in adults with isolated genetic dystonias. Dystonia in childhood is more commonly a symptomatic condition, with dystonia frequently expressed on the background of a structurally abnormal brain. Outcomes following DBS in this setting are much more variable, the reasons for which have yet to be elucidated. Much of the focus on improving outcomes following DBS in dystonia management has been on the importance of patient selection, with, until recently, little discussion of the choice of target. In this review, we advance the argument that patient selection for DBS in childhood cannot be made separate from the choice of target nuclei. The anatomy of common DBS targets is considered, and factors influencing their choice for electrode insertion are discussed. We propose an “ABC” for DBS in childhood dystonia is proposed: Appropriate Child selected; Best nuclei chosen for electrode insertion; Correct position within that nucleus.
Journal: European Journal of Paediatric Neurology - Volume 21, Issue 1, January 2017, Pages 176-184