کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5629519 | 1580272 | 2017 | 10 صفحه PDF | دانلود رایگان |
- The largest series of skull base osteosarcomas were reported and relevant literature reviewed.
- It is difficult to achieve oncological complete resection due to the complex anatomy and vital structures involved.
- Skull base osteosarcoma has a poorer prognosis compared with long bone and head and neck osteosarcoma.
- Maximum-safe resection with comprehensive treatment is most appropriate for skull base osteosarcoma.
BackgroundOsteosarcoma of the skull base is rarely observed; most published studies comprise case reports. The clinical features and optimal treatments have not been clearly established. The purpose of this article is to present 19 cases of skull base osteosarcoma and review the literature to analyse the clinical features and treatment of skull base osteosarcoma.MethodsThe clinical data of 19 patients with skull base osteosarcoma from January 2005 to December 2016 were retrospectively analysed; pertinent English literature from 1976 to 2016 was reviewed.ResultsSix female and 13 male patients were included. The ages ranged from 11 to 55Â years (mean 34Â years). Gross-total resection of the tumour was achieved in 13 cases, and nearly total resection was achieved in 6 cases. Five cases were treated with surgery alone, whereas 14 cases received comprehensive treatment. The follow-up period ranged from 3 to 132Â months (mean 33Â months) with 17 patients who underwent follow-up. The median survival durations of the patients who underwent surgery alone and who received comprehensive treatment were 18 and 50Â months, respectively. The literature results were similar to the current findings. Overall, the 5-year survival rates of the patients in our series and in the literature were 30.5% and 37.8%, respectively.ConclusionsSkull base osteosarcoma had a low complete resection rate, a high recurrence rate and a poor prognosis because of the complex anatomy and vital structures involved. Radical surgery with comprehensive treatment is most appropriate for this disease.
Journal: Journal of Clinical Neuroscience - Volume 44, October 2017, Pages 133-142