کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5629802 1580278 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Case studySafety of remifentanil in transsphenoidal surgery: A single-center analysis of 540 patients
ترجمه فارسی عنوان
مطالعه موردی ایمنی رمی فنتانیل در جراحی ترانسفنوئیدی: یک مطالعه تک محوری از 540 بیمار
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Remifentanil is used in transsphenoidal surgery for its hemodynamic properties.
- Remifentanil suppresses cough and controls blood pressure.
- Complications in transsphenoidal cases may differ from other operations.
- No difference in complications between patients with and without remifentanil.

Although some studies have examined the efficacy and safety of remifentanil in patients undergoing neurosurgical procedures, none has examined its safety in transsphenoidal operations specifically. In this study, all transsphenoidal operations performed by a single author from 2008 to 2015 were retrospectively reviewed to evaluate the safety of remifentanil in a consecutive series of patients. During the study period, 540 transsphenoidal operations were identified. Of these, 443 (82.0%) patients received remifentanil intra-operatively; 97 (18.0%) did not. The two groups were well-matched with regard to demographic categories, comorbidities, and pre-operative medications (p > 0.05), except pre-operative tobacco use (p = 0.021). Patients were also well-matched with regard to radiographic features and surgical techniques. Patients who received remifentanil were more likely to harbor a macroadenoma (78.1% vs. 67.0%, p = 0.025), and had slightly longer anesthesia time on average (269.2 min vs. 239.4 min, p = 0.024). All pathologic diagnoses were well-matched between the two groups, except that patients receiving remifentanil were more likely to harbor a non-functioning adenoma (46.5% vs. 26.8%, p < 0.001). Analysis of post-operative complications showed no significant difference between patients who received remifentanil and those who did not, and length of stay and prevalence of ICU stay did not differ between the two groups. In a well-matched series of 540 patients undergoing transsphenoidal surgery, remifentanil was found to be a safe anesthetic adjunct. There were no significant differences in post-operative hospital course or complications in patients who did and did not receive intra-operative remifentanil.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 38, April 2017, Pages 96-99
نویسندگان
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