کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5629818 1580280 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pre- and postoperative neurocognitive deficits in brain tumor patients assessed by a computer based screening test
ترجمه فارسی عنوان
نقص عصبی قبل و بعد از عمل در بیماران مبتلا به تومور مغزی با استفاده از آزمون غربالگری مبتنی بر کامپیوتر ارزیابی شد
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Computer based screening is a valuable method to assess neurocognitive deficits in brain tumor patients.
- Most brain tumor patients show significant deficits in various neurocognitive domains before initiation of tumor treatment.
- The majority of brain tumor patients do not experience significant neurocognitive deterioration after tumor surgery.

Neurocognitive assessment becomes increasingly important in neuro-oncology. The presence and degree of neurocognitive deficits in patients with brain tumors appear to be important not only as outcome measures but also in treatment planning and as possible prognostic markers for tumor-progression. Common screening methods for neurocognitive deficits are often insufficient in uncovering subtle changes or harbor the risk of being observer-dependent and time-consuming. We present data of brain tumor patients screened by a computer-based neurocognitive assessment tool before and after surgery. 196 patients with tumor resections were tested at our institution using the NeuroCog Fx® software 2 days before and 3-4 months after surgery. Additionally to the test results, patient-related information, such as age, sex, handedness, level of education, pre- and postoperative neurological status, KPS, location and histopathological diagnosis were recorded. These prospectively collected results were correlated in the here presented retrospective study. The majority of patients with malignant gliomas, metastases and meningiomas showed significant deficits in various neurocognitive domains, most of them improved or did not decline in their postoperative neurocognitive performances. Interestingly, there was no significant correlation of neurocognitive deficits and brain tumor location. In future, standardized neuropsychological assessment should become an essential part of the management and care of patients with brain tumors to provide a more personalized and tailored treatment. Further studies will improve the understanding of the influence of various treatment modalities on neuro-cognition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 36, February 2017, Pages 31-36
نویسندگان
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