کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5631996 | 1406522 | 2017 | 7 صفحه PDF | دانلود رایگان |

- PGM1 deficiency is associated with severe exercise intolerance due to a block in skeletal muscle glycogenolytic capacity.
- Oral galactose treatment in adults with PGM1 deficiency is safe and improves walking distance.
- Galactose treatment tends to normalize skeletal muscle substrate use from fat to carbohydrates during exercise.
Mutations in PGM1 (phosphoglucomutase 1) cause Glycogen Storage Disease type XIV, which is also a congenital disorder of protein N-glycosylation. It presents throughout life as myopathy with additional systemic symptoms. We report the effect of oral galactose treatment during five months in a patient with biochemically and genetically confirmed PGM1 deficiency. The 12-minute-walking distance increased by 225âm (65%) and transferrin glycosylation was restored to near-normal levels. The exercise assessments showed a severe exercise intolerance due to a block in skeletal muscle glycogenolytic capacity and that galactose treatment tended to normalize skeletal muscle substrate use from fat to carbohydrates during exercise.
Journal: Neuromuscular Disorders - Volume 27, Issue 4, April 2017, Pages 370-376