کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5632219 1406530 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewFocal myositis: A review
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
ReviewFocal myositis: A review
چکیده انگلیسی


- Focal myositis (FM) is an isolated rapidly growing intramuscular mass.
- MRI shows a contrast enhanced solitary mass or hypertrophy of a single muscle.
- Muscle biopsy confirms the diagnosis and specifies the cause.
- Self-regression within a few weeks is usual.
- Steroids are recommended in FM caused by a nerve lesion or related to an auto-immune process.

Amongst the heterogeneous group of inflammatory myopathies, focal myositis stands as a rare and benign dysimmune disease. Although it can be associated with root and/or nerve lesions, traumatic muscle lesions and autoimmune diseases, its triggering factors remain poorly understood. Defined as an isolated inflammatory pseudotumour usually restricted to one skeletal muscle, clinical presentation of focal myositis is that of a rapidly growing solitary mass within a single muscle, usually in the lower limbs. Electromyography shows spontaneous activity associated with a myopathic pattern. MRI reveals a contrast enhanced enlarged muscle appearing hyper-intense on FAT-SAT T2 weighted images. Adjacent structures are spared and there are no calcifications. Serum creatine kinase (CK) levels are usually moderately augmented and biological markers of systemic inflammation are absent in most cases. Pathological histological features include marked variation in fibre size, inflammatory infiltrates mostly composed of T CD4+ lymphocytes and macrophages, degenerating/regenerating fibres and interstitial fibrosis. Differential diagnoses are numerous and include myositis of other origin with focal onset. Steroid treatment should be reserved for patients who present with major pain, nerve lesions, associated autoimmune disease, or elevated C reactive protein or CK.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 26, Issue 11, November 2016, Pages 725-733
نویسندگان
, , , ,