Original ArticleSleep Problems in Children With Agenesis of the Corpus Callosum

BackgroundVery little is known about sleep habits in children with agenesis of the corpus callosum (ACC). The purpose of this investigation was to evaluate sleep problems in children with ACC and examine the association with quality of life.MethodsWe performed a cross-sectional, anonymous, internet-based survey offered to parents of children with ACC, aged five to 18 years. The Children's Sleep Habits Questionnaire (CSHQ) and pediatric quality of life (PedsQL) were used to assess sleep habits and quality of life, respectively. Associations between the total and all subdomains of CSHQ and PedsQL were tested.ResultsThe final sample included 66 parents of children with ACC. Overall, 78% of the children had clinically significant sleep problems, using a cutoff score of 41 on the CSHQ. Compared with a prior national sample of typically developing children, children with ACC scored significantly higher overall and in all subdomains of the CSHQ. The overall CSHQ and PedsQL were moderately correlated (r = −0.485, P < 0.001), indicating that children with more sleep problems had worse quality of life. In addition, the total CSHQ correlated with all subdomains of the pediatric quality of life, including emotional (r = −0.515, P < 0.01), social (r = −0.394, P < 0.01), physical (r = −0.263, P < 0.01), and school (r = −0.362, P < 0.01). These associations remained statistically significant in multivariable regression models controlling for age and gender.ConclusionsSleep problems are common and associated with lower quality of life in children with ACC.